Add ground beef to a large skillet over medium-high heat then lightly season with salt and pepper, and cook until no longer pink. Drain, then return to the skillet off the heat and stir in in ketchup, mustard, and Worcestershire sauce to taste.* (A good ratio to follow is 3 parts ketchup, to 2 parts mustard, and 1 part Worcestershire sauce.)
Lay tortillas out then spread 1/4 of the seasoned ground beef on one half of each tortilla. Top with toppings of choice then fold over tortilla.
Spray a large skillet with non-stick spray. Cook over medium heat until golden brown on one side, then flip and cook until golden brown on the other side. Remove to a cutting board to cool for a few minutes, then slice into wedges with a pizza cutter.